TFD™ Technology: targeted delivery to the follicular niche

The TFD™ (Targeted Follicular Delivery) platform concentrates encapsulated actives exactly where we want them: the follicular niche, around the follicle opening and its micro-environment (peri-follicular area, sebaceous gland, adjacent matrix).

Thanks to this technology:

  • Actives are protected inside a lipid membrane from pH shifts, oxidation and incompatibilities within the formula.
  • It supports localised, non-invasive penetration, navigating the upper scalp layers without aggressive methods.
  • Each exosome carries a high load of active ingredients, with controlled, time-modulated release for sustained exposure.
  • The biomimetic membrane composition enhances cell affinity and biocompatibility, favouring local bioavailability and coherent signalling.

This is a non-medical cosmetic technology, created to raise the performance of hair formulations whilst maintaining excellent skin tolerance.

The bioexosomes we work with

In this first generation of products with TFD™ Technology we work with two main profiles of biomimetic exosomes, enriched with botanical fractions rich in polyphenols, flavonoids and phytosterols:

1. Azelaic Acid + Encapsulated Herbal Complex

Designed for oily scalps, flaking and microbiome imbalance.

This profile acts on:

  • The appearance of excess sebum and root shine.
  • Surface renewal and skin texture, reducing the look of hyperkeratinisation and build-up.
  • Peri-follicular comfort on reactive scalps or those prone to itching sensations.

Key botanicals encapsulated within the exosomes:

  • Chamomile (Matricaria chamomilla): helps soothe and soften.
  • Nasturtium (Tropaeolum majus): supports signals of vitality and a sensation of a more “oxygenated” scalp.
  • Burdock (Arctium lappa): assists with the removal of surface impurities and follicular residues.
  • Sage (Salvia officinalis): offers purifying and sebum-balancing properties.

2. Red Clover + Acetyl Tetrapeptide-3 + Beta-sitosterol

A profile focused on hair with reduced density, thinning tendencies and scalps that need support for homeostasis and anchoring.

  • Acetyl Tetrapeptide-3: supports the collagen III/IV network and laminins associated with the follicular anchoring structure.
  • Red Clover (Trifolium pratense): rich in isoflavones (including biochanin A); provides antioxidant and comfort benefits, helping to maintain a favourable peri-follicular micro-environment.
  • Beta-sitosterol: a widely used phytosterol in scalp cosmetics; contributes to balance and comfort around the follicle.

In both cases, the TFD™ platform is responsible for guiding these actives to the follicular niche and releasing them gradually, for consistent cosmetic performance.

Bio-exosomal Trichology: from idea to reality

For many years we have had a clear vision: to bring cellular biotechnology and advanced signalling into scalp and hair care, with a purely cosmetic approach that can be reproduced in-clinic and at home. The level of technology required to do this with our desired precision simply did not exist – until now.

The EXOSOME LINE – Cellular Hair Biotech was created from that vision: seamlessly combining biomimetic exosomes, TFD™ Technology and advanced botanical–biotechnological complexes to offer high-precision protocols designed for modern trichological practice.

What concerns do we address with this technology?

A complete architecture for the main scalp needs

Using TFD™ Technology and our bioexosomes, we have developed specific shampoos and treatments that cover the key scalp concerns:

  • Hair loss prevention and support for density
    – HAIR LOSS PREVENTION SHAMPOO+
  • Sebum control and oily roots
    – SEBUM CONTROL SHAMPOO+
  • Dandruff, flaking and scalp irritation
    – DANDRUFF & SCALP CARE SHAMPOO+
  • Fine, fragile or low-density hair
    – HAIR NUTRIENT ROYAL JELLY SHAMPOO+
    – VOLUME THERAPY SHAMPOO+
  • Impaired oxygenation and lack of balance in the follicular environment
    – ATP OXYGEN EQUILIBRIUM SHAMPOO+
  • Damaged or very dry hair fibres requiring deep cosmetic repair
    – NUTRI FIBER MOISTURIZING SHAMPOO+
    – TRIPLE ACTION CONDITIONER DEEP REPAIR+
    – DERMO CAPILLARY MASK ACTIVATED+
  • Colour-treated hair with a tendency to fragility and hair loss
    – HAIR LOSS & COLORS SHAMPOO+

Each reference combines TFD™ bioexosomes with peptide complexes, vitamins, azeloglycine, neurocosmetic agents, marine ingredients and botanicals to deliver scalable protocols: in clinic / salon and at home, with reproducible cosmetic results.

Benefits for professionals and end-users

For the trichological professional

  • A scientifically supported platform, with detailed technical documentation on actives and mechanisms.
  • Standardised protocols, easy to integrate into daily practice (diagnosis + in-cabin treatment + home maintenance).
  • A differentiated line built on TFD™ biomimetic exosomes, positioning the centre as a reference in advanced hair science.

For the end-user

  • Hair that feels fuller and more vital from the roots.
  • A more balanced, comfortable scalp, with improved control of oiliness, dandruff or sensitivity according to the chosen protocol.
  • Hair that appears stronger, smoother and shinier, without compromising on lightness or cosmetic elegance.

Bring Bio-exosomal Trichology into your clinic or salon

If you are a distributor, clinic or specialised salon:

  • Request the complete EXOSOME LINE – Cellular Hair Biotech portfolio.

  • Access technical training, protocols and supporting materials for your team.

  • Integrate a line powered by TFD™ Technology and biomimetic bioexosomes, designed to work with precision in the follicular niche.

Simone Trichology – Bioexosomal Trichology: the future applied to today’s hair.

TFD bio-exosomal hair care technology by Simone Trichology